MegaSpore Probiotics

MegaSpore Probiotics

MegaSpore Probiotic

Pathways is proudly carrying the new and improved formula of Megaspore Priobiotics. Megaspore created a new formula and performed a study with AMAZING results! Please see below:

This groundbreaking study on MegaSporeBiotic, published in the August 15th, 2017 issue of The World Journal of Gastrointestinal Pathophysiology is indeed a game changer!  This study demonstrates the incomparable effects of our proprietary, bacillus, multi-spore formulation on the gut, its structure, function as well as its connection to the immune system and the brain!

  • The study screened nearly 100 young, healthy subjects for Metabolic Endotoxemia and discovered that nearly 50% of this population exhibited this endotoxic response to a high caloric meal. Nearly half of young, healthy, normal weight, symptom-free individuals had a highly toxic response to eating food. The same toxic response that is responsible for causing metabolic syndrome, obesity, diabetes, autoimmunity, cancers and heart disease. This finding itself was surprising and quite staggering. 

  • Just 30 days of taking MegaSporeBiotic, significantly reduced the endotoxic response to the same challenge meal, along with significant reductions in triglycerides, IL-6, IL-8, IL-1B and MCP-1. It is important to note, that no other interventions, dietary modifications or lifestyle changes were imposed on these subjects. The only change was taking MegaSporeBiotic or a placebo. Just 30 days of taking MegaSporeBiotic, effectively fixed their gut lining, favorably altered the immunological response to food, significantly decreased both digestive and systemic inflammation, and in doing so, reduced a major hallmark of chronic degenerative disease.

  • Another significant finding was that MegaSporeBiotic was able to restore some communication between the gut and the brain, that was seemingly lost in most of these subjects. The levels of ghrelin (the hunger hormone) remained elevated in the placebo subjects, even after consuming a high caloric meal. This indicates that the gut
    is not communicating the energy status of the digestive tract to the brain, thus the hunger hormone continued to remain high after the meal. After 30 days on MegaSporeBiotic, we saw a restoration of ghrelin function and gut-brain communication, where the treatment group recorded a dramatic reduction in circulating ghrelin hormone after the high caloric meal. The lost communication on energy status and caloric intake between the gut and the brain was restored by MegaSporeBiotic.

  • In the subjects that did have an endotoxic response, their microbiome was not protective of the host. With 30 days of MegaSporeBiotic, the microbiome was changed from a non-protective confirmation to a protective confirmation, blocking the influx of highly toxic LPS into the circulation after a meal. 

  • The 30 days of MegaSporeBiotic therapy also trended towards a better insulin response to the challenge meal, indicating that Megaspore likely conducts a favorable modulation of the endocrine response to food. 

  • The systemic, chronic immune activation from leaky gut is believed to be the driving force behind autoimmunity and inflammatory bowel disease, this response got worse by about 32% in the placebo group. This means in just 30 days, the condition got worse by a measurable amount. Conversely, the Megaspore group saw a significant reduction in chronic immune activation by using the spores. This can have significant implications for the treatment and management of autoimmune disease and inflammatory bowel disease. 

  • This is the first time that a probiotic has been shown to significantly reduce leaky gut and all the associated immune activation, in human subjects. 


Pathways has a PDF version of this study available, and if you would like a copy for yourself, please just let us know and we will happily send it to you. Thanks!


Understanding the Gut-Brain Connection

Did you know that the gut microbiome functions like a second brain?

 The brain and the gut both develop from the same tissue during fetal development. One part becomes the central nervous system, while the other develops into the enteric nervous system. They are connected via the vagus nerve which allows the gut to operate as a large, semi-autonomous brain with its own elaborate endocrine signaling system. In this way, research has shown that the gut can directly influence the brain.

 Studies show that both beneficial and pathogenic bacteria in the gastrointestinal tract can activate neural pathways and central nervous system signaling.The gut microbiome is affected by our experiences and emotions; and in turn, the microbes in our gut can send chemical signals (including neurotransmitters) that affect memory, emotions, and behavior in important parts of the brain.

Recent studies have found that:

  • Campylobacter jejuni infections can exacerbate anxiety (1)

  • Gut bacteria can control food cravings (2)

  • Children with autism have less diverse microbiomes than symptom-free children (3)

  • Patients with anorexia nervosa have significantly reduced total    gut bacteria (4)

  • Some antibiotics can induce psychosis (5)

 As you can see, recent research suggests that neurological conditions may actually begin in the gut; and as a result, rebalancing the gut microbiome could be the key to treating many of these conditions.

One of the best ways to recondition the gut is by supplementing with spore-based probiotics, like MegaSporeBiotic. In fact, MegaSporeBiotic has been shown to increase microbial diversity in the gut by 40%.

If you’d like more information on the gut-brain axis, click on the link below:

Click here to watch the webinar.